GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1468333 | 1 | rs4552585 | chr5:137533159 | KLHL3 | chr5:136953190-137071779:- | -0.13 | -3.52 | 0.000475 | Resting heart rate |
| THCA | cis | rs10789491 | 1 | rs4553120 | chr1:47165729 | CYP4B1 | chr1:47264670-47285020:+ | 0.22 | 3.45 | 0.00061 | Response to hepatitis C treatment |
| THCA | cis | rs10789491 | 1 | rs4553120 | chr1:47165729 | CYP4Z1 | chr1:47533160-47583992:+ | 0.27 | 4.08 | 5.37E-5 | Response to hepatitis C treatment |
| THCA | cis | rs10789491 | 1 | rs4553120 | chr1:47165729 | DMBX1 | chr1:46972668-46979884:+ | 0.24 | 4.05 | 5.88E-5 | Response to hepatitis C treatment |
| THCA | cis | rs8014204 | 1 | rs4553560 | chr14:75334199 | MLH3 | chr14:75480467-75518235:- | -0.13 | -3.47 | 0.000567 | Caffeine consumption |
| THCA | cis | rs8014204 | 1 | rs4553560 | chr14:75334199 | RPS6KL1 | chr14:75372347-75389958:- | -0.33 | -6.76 | 3.98E-11 | Caffeine consumption |
| THCA | cis | rs7219021 | 1 | rs4553671 | chr17:46848272 | CALCOCO2 | chr17:46908372-46942228:+ | -0.13 | -3.51 | 0.000487 | Schizophrenia or bipolar disorder |
| THCA | cis | rs7219021 | 1 | rs4553671 | chr17:46848272 | SNF8 | chr17:47007461-47022154:- | -0.25 | -7.19 | 2.47E-12 | Schizophrenia or bipolar disorder |
| THCA | cis | rs7219021 | 1 | rs4553671 | chr17:46848272 | UBE2Z | chr17:46985767-47006422:+ | -0.19 | -3.95 | 9.16E-5 | Schizophrenia or bipolar disorder |
| THCA | cis | rs72627123 | 1 | rs45559033 | chr14:74341124 | LIN52 | chr14:74551656-74667117:+ | 0.25 | 4.56 | 6.56E-6 | Morning vs. evening chronotype |
| THCA | cis | rs72627123 | 1 | rs45559033 | chr14:74341124 | PTGR2 | chr14:74318534-74352166:+ | 0.22 | 3.57 | 0.000387 | Morning vs. evening chronotype |
| THCA | cis | rs72627123 | 1 | rs45559033 | chr14:74341124 | ZNF410 | chr14:74318674-74398803:+ | 0.22 | 3.74 | 0.000205 | Morning vs. evening chronotype |
| THCA | cis | rs9346353 | 1 | rs45559535 | chr6:70447993 | LMBRD1 | chr6:70385751-70506888:- | -0.1 | -3.47 | 0.000566 | Sleep duration |
| THCA | cis | rs6479874 | 1 | rs4558117 | chr10:52780284 | PRKG1 | chr10:52750945-54055274:+ | -0.22 | -5.01 | 7.75E-7 | Migraine |
| THCA | cis | rs4802307 | 1 | rs45587933 | chr19:46886234 | CCDC8 | chr19:46913587-46916919:- | -0.2 | -3.37 | 0.000827 | Crohn's disease;Inflammatory bowel disease |